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Peptides with Anti-Cancer Properties

A review of the scientific biomedical literature reveals that many peptides have anti-cancer activities or properties. The following table contains a list of peptides reported to have anti-cancer activities against solid and hematological tumors. Their oncolytic properties, or their ability to destroy tumor cells, are shown here as well. [Gaspar et al. 2013].
 
Peptides with Anti-Cancer Properties
 

Peptide

Amino acid sequence

Anticancer Activity

Cancer Cell

D-peptide A

D-peptide B

D-peptide C

D-peptide D

 RLYLRIGRR

 RLRLRIGRR

 ALYLAIRRR

 RLLLRIGRR

Cell membrane

disruption

Human cervix, glioma,

lung, mouse myeloma,

African green monkey

kidney

D-K6L9

 LKLLKKLLKK LLKLL

Necrosis via

membrane

depolarization

Human prostate

NRC-03

 GRRKRKWLRR IGKGVKIIGG

 AALDHL

Cell membrane lysis

Human breast

NRC-07

 RWGKWFKKAT HVGKHVGKAA

 LTAYL

Cell membrane lysis

Human breast

Gomesin

 ZCRRLCYKQR CVTYCRGR

Unclear

Murine melanoma, human breast, colon and cervix adenocarcinoma

Hepcidin TH2-3

 QSHLSLCRWC CNCCRSNKGC

Cell membrane lysis

Human cervix, hepatocellular carcinoma, fibrosarcoma

Dermaseptin B2

 GLWSKIKEVG KEAAKAAAK

 AAGKAALGAV SEAV

Necrosis

Human prostate and breast

PTP7

 FLGALFKALS KLL

Apoptosis induction

Human lung, breast and hepatocellular carcinoma

MGA2

 GIGKFLHSAK KFGKAFVGEI

 MNSGGKKWKM RRNQF–WVKVQRG

Necrosis and apoptosis

Cervix and lung, melanoma, rat glioma

HNP-1

 ACYCRIPACI AGERRYGTCI

 YQGRLWAFCC

Mediation of antitumor immunity

Mouse colon and brest

Tachyplesin

 KWCFRVCYRG ICYRRCR

Activation of the classic complement pathway

Human prostate

Temporin-1CEa

 FVDLKKIANI INSIF

Membrane disruption, calcium release, ROS production

Human breast

NK-2

 KILRGVCKKI MRTFLRRISK

 DILTGKK

Necrotic death after peptide intercalation into phospholipid phosphatidylserine -containing membranes.

Human chronic myelogenous leukemia, histiocytic lymphoma, acute T cell leukemia, acute lymphoblastic leukemia, neuroblastoma, colorectal adenocarcinoma

Bovine lactoferricin B6 (LbcinB6)

 RRWQWR

Apoptosis, disruption of mitochondrial membrane

Human acute lymphoblastic T leukemia, acute T cell leukemia

Cecropin CB1

 KWKVFKKIEK MGRNIRNGIV

 KAGPKWKVFK KIEK

Unclear

Human acute lymphoblastic T leukemia, lung carcinoma, stomach carcinoma

 

Reference
Gaspar D, Veiga AS, Castanho MA. From antimicrobial to anticancer peptides. A review. Front Microbiol. 2013 Oct 1;4:294. [PMC]
 
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