BIO-SYNTHESIS provides
custom peptides
and has developed a proprietary synthesis strategy that allows the
synthesis of peptides up to about 120 residues - with purity and speed,
generally only possible with shorter peptide fragments.
Since most biologically active proteins are about 150 residues in length, however,
it has been shown that most activity is kept within 100 residues. Most commercial
proteins are made by recombinant methods, whereby genes coding for particular peptide
sequences are inserted into a host organism, for bulk synthesis. While the endotoxin
contamination can be problematic for recombinant methods, chemical synthesis offers
much cleaner products.
BSI has decades of experience in synthesizing >500,000
custom peptides
many of them long peptides. This growing field of
long peptide synthesis
uses peptide or peptide like compounds for pharmaceutical drug discoveries.
However, the challenge of
long peptide synthesis
is to overcome the enormous cumulative effect of the yield. Synthetic inefficiencies
associated with peptide aggregation, such as slow or incomplete coupling and/or
deprotection reactions, illustrate the complexity that often arises.
Bio-Synthesis has developed a solid-phase synthesis technology that overcomes these
limitations, achieving syntheses of large proteins entirely by chemical methods.
Our team of experts will examine your protein of interest and will assess feasibility
to maximize the success of the synthesis from long and difficult peptides.
For a quotation on long peptide synthesis, click
here!