Steary C18, lipophilic Carrier
Steary C18 lipid has become a favorable lipophilic carrier in siRNA and antisense therapeutic studies. This modification can be placed at the 5' end of an oligonucleotide. Antisense oligonucleotides, siRNA, aptamers, and miRNA have been used in various therapeutic developments. However, the challenge facing these developments has been how to deliver the oligos effectively to the desired cellular targets. Strategies of using lipophilic and non-toxic carrier such as Steary C18 lipid, choleseryl-TEG, a-Tocopherol-TEG, GalNAc have been used. Related Products:
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Product Information
Steary C18, lipophilic Carrier
antisense, siRNA, Lipophilic Carrier
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
References/Citations:
- C. Wolfrum, et al., Nat Biotechnol, 2007, 25, 1149-57.
- H. Liu, B. Kwong, and D.J. Irvine, Angew Chem Int Ed Engl, 2011, 50, 7052-5.
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