Serninol Nucleic Acid, SNA
Bio-Synthesis offer Serinol nucleic Acid, SNA synthesis services. This class of backbone modified nucleic acid analogs are used to minic the structure and function of natural RNA as well as DNA. Study have shown SNA modified oligo are capable of reducing melting temperature by 0.5-12 oC depnd on the sequence and location of substitution 1,2.
SNA oligonucleotides will hybridize with SNA, RNA, as well as DNA to form right-handed helices, and the resulting structures are relatively stable3. SNA oligo binds RNA more strongly than DNA and SNA is very stable to nuclease4.
Key Features of SNA Oligonucleotides:
Enhanced Stability: Compared to natural nucleic acids, SNAs are more stable, making them more resistant to enzymatic degradation. This allows for various applications in biological systems.
High Binding Affinity: The altered backbone structure of SNAs can result in more robust and specific binding to complementary nucleic acid sequences, which is helpful for
applications in diagnostics and therapeutics, where precise targeting is essential.
Resistance to Nucleases: Synthetic SNAs are not easily recognized and degraded by nucleases, enzymes that typically break down natural nucleic acids. This extends the functional lifespan of SNAs in biological environments.
Applications Gene Therapy: Oligonucleotides modified with SNAs enable the delivery of therapeutic genes or oligonucleotides into cells. Their stability and binding properties enhance the efficiency and effectiveness of gene delivery.
Diagnostics: In diagnostic assays, SNAs can be employed as probes to detect specific nucleic acid sequences. Their high specificity and resistance to degradation improve the accuracy and reliability of these tests.
Antisense and RNAi Therapies: Well-designed SNA oligonucleotide can selectively bind to mRNA transcripts and modulate gene expression. This application is particularly relevant for developing treatments for genetic diseases and viral infections.
Research Tools: SNAs can serve as valuable tools in molecular biology research, enabling the study of nucleic acid interactions and the development of new biotechnological methods.
Product Information
Serninol Nucleic Acid, SNA
[SNA-A][SNA-C][SNA-G][SNA-T]
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at 20°C) in a nuclease-free environment should be stable for years.
References/Citations:
- K.S. Ramasamy, and W. Seifert, Bioorg Med Chem Lett, 1996, 6, 1799-1804.
- R. Benhida, M. Devys, J.-L. Fourrey, F. Lecubin, and J.-S. Sun, Tetrahedron Lett, 1998, 39, 6167-6170.
- H. Kashida, K. Murayama, T. Toda, and H. Asanuma, Angew Chem Int Ed Engl, 2011, 50, 1285-8.
- B.T. Le, K. Murayama, F. Shabanpoor, H. Asanuma, and R.N. Veedu, RSC Advances, 2017, 7, 34049-34052.
- Y. Kamiya, et al., Chembiochem, 2014, 15, 2549-55.
- K. Murayama, Y. Kamiya, H. Kashida, and H. Asanuma, Chembiochem, 2015, 16, 1298-301.
- H. Kashida, et al., Chem Sci, 2021, 12, 1656-1660.
- The Glen Report, 2008, 20.2, 6,7,16. The Glen Report, 2013, 25.1, 4-5.
- Y. Kamiya, et al., Chem Asian J, 2020, 15, 1266-1271.
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