N2-Methyl-2'-Deoxyguanosine (N2-Methyl-dG) Oligonucleotide Modification
Guanine bases in DNA are susceptible to N-alkylation by various carcinogens, leading to miscoding and mutagenicity. Choi and Guengerich have prepared a series of N2-alkyl-2'-deoxyguanosine modified DNA bases where where the alkyl group ranges in size from methyl to anthracenylmethyl for studies on the effect of the size of these groups on the catalytic efficiency and fidelity of various DNA polymerases.1
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N2-Methyl-2'-Deoxyguanosine (N2-Methyl-dG) Oligonucleotide Modification
Modified DNA, Epigenetic, Mutagenesis Studies
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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