8-Amino-2'-deoxyguanosine, 8-Amino-dG
8-Amino dA and 8-amino-dG, are 8-amino-puridines that are often used in the study of triplex (triple helix) formation due to the presence of an additional amino group. The 8-amino group is able to form an additional Hoogsteen purine-pyrimidine hydrogen bond, which serves to increase triple helix stability. Studies have shown that triple-helix-forming oligos (TFO) containing 8-amino-dA form stable helices at a neutral pH, instead of under acidic conditions.
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Product Information
8-Amino-2'-deoxyguanosine, 8-Amino-dG
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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