3'-Riboguanosine, 2'-5' Linked Oligonucleotide Modification
3'-riboguanosine, 3'-rG Oligonucleotide modification use to substitute 2'-5' phosphodiester linkage for usual 3'-5' linkage at same or all position of an oligonucleotide. This oligonucleotide modification often use in the antisense application as ssRNA specific probes, or as ligands for affinity purification for cellular RNA. Contact Bio-Synthesis for 2-'5' linked oligonucleotide synthesis.
Product Information
3'-Riboguanosine, 2'-5' Linked Oligonucleotide Modification
Mino base, Antisense, Affinity Ligand
-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
References/Citations:
- Giannaris, P.A.; Damha, M.J. Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA. Nucleic Acids Res (1993), 21: 4742-4749. - 3'-rU (2'-5' linked)
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