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2,6-Diaminopurine-2'-deoxyriboside,  2-Amino-2'-deoxyadenosine, DAPdR are deoxyadenosine analogs. These modified DNA analogs are often used to substitute A bases to increase primer duplex stability since the 2-amino-A-T base pair is equivalent in strength to the G-T base pair. 2-Amino-A also destabilizes A-G wobble mismatches, thus increasing specificity.

See a list of our duplex stabilizing bases

Product Information

 

Product Name:

2,6-Diaminopurine-2'-deoxyriboside (DAPdR) Oligonucleotide Modification

Category:

Modified Bases; Duplex Stabilizing Base

Modification Code:

[DAPdR]

Chemical Formula:

C10H13N6O5P

Exact Mass:

328.07

Formula Weight:

328.23

Structure:

Bio-Synthesis Inc. Oligo Structure

Purification:

HPLC or PAGE

Delivery Format:

Lyophilized

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.


References/Citations:

1. "Metabolic activation of 2,6-diaminopurine and 2,6-diaminopurine-2′-deoxyriboside to antitumor agents" by GisbertWeckbeckerJoseph G.Cory; Advance in Enyzme Regulation Volume 28, 1989 p.125-144
2. Fernández-Sierra M, Shao Q, Fountain C, Finzi L, Dunlap D.E. coli Gyrase Fails to Negatively Supercoil Diaminopurine-Substituted DNA.J Mol Biol. 2015 Jul 3
3. Lazinski DW, Camilli A. Homopolymer tail-mediated ligation PCR: a streamlined and highly efficient method for DNA cloning and library construction. Biotechniques. 2013 Jan;54(1):25-34.