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Will coupling agent or cross linker used to conjugate peptide elicit immuno response

Coupling agent or cross linker elicit immuno response?

Yes, most people do not realize antibodies can be generated to the cross linker used to link the peptide to a carrier protein. It is therefore advisable to prepare two conjugates of the same peptide with different carrier proteins and different coupling method when placing order.

Useful Reading:

"The generation of antibodies to the couplig agent used for the peptide conjugation"

"Immunogenicity of new heterobifunctional cross-linking reagents used in teh conjugation of synthetic peptides to liposomes"