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how thiol linker is attach to an oligo at 5' and 3' end

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07/06/2018

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Could you please let me know how the thiol linker is attached to the DNA on both end?

Below is the illustration of oligo with 5' C6 thiol and 3' C3 thiol modification with final strcture after TCEP/DTT reduction

Thiol modified oligo synthesis

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07/06/2018

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how thiol linker is attach to an oligo at 5' and 3' end

Could you please let me know how the thiol linker is attached to the DNA on both end?

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