Notch 1 (1735 - 1752)
Sequence (1LC):
VLLFFVGCGVLLSRKRRR
Sequence (3LC):
NH2 - Val - Leu - Leu - Phe - Phe - Val - Gly - Cys - Gly - Val - Leu - Leu - Ser - Arg - Lys - Arg - Arg - Arg - COOH
Price/Unit:
$710
(For other quantities please
Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This is amino acids 1735 to 1752 fragment of Notch 1 containing the gamma-secretase-like cleavage site between Gly1743 and Val1744. This Val1744 residue is conserved in the Notch family, it is critical for the cleavage of Notch 1. A corresponding Val residue exists in APP and APLP2 but not in APLP1. Notch 1 belongs to the epidermal growth factor-like family; however recent studies suggest there is a reciprocal relationship between gamma--cleavage and notch site cleavage.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Reference/Citations:
- Morishima-Kawashima, M. et al. Molec. Mech. Epoch. Ther. Ischemic Stroke 1252, 347 (2003);
- Gu, Y., et al. J. Biol. Chem. 276, 35235 (2001).