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[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)

[NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)
Sequence (1LC):
NF-(NMe-G)-A-(NMe-I)-L
Sequence (3LC):
H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH
Catalog :
10069-01
Unit:
1 mg
Price/Unit:
$728  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Lyophilized solid, trifluoroacetate (TFA) salt format
Description:
This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.
Storage:
-20°C
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
661.8
Reference/Citations:
  1. Yan, L. et al. PNAS 103, 2046 (2006),
  2. Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002),
  3. Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).