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Nβ25; Notch - 1 Aβ - like Peptide

Nβ25; Notch - 1 Aβ - like Peptide
Sequence (1LC):
VKSEPVEPPLPSQLHLMYVAAAAFV
Sequence (3LC):
NH2 - Val - Lys - Ser - Glu - Pro - Val - Glu - Pro - Pro - Leu - Pro - Ser - Gln - Leu - His - Leu - Met - Tyr - Val - Ala - Ala - Ala - Ala - Phe - Val - COOH
Catalog :
13937-01
Unit:
1 mg
Price/Unit:
$950  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This 25-mer Notch-1 Aβ-like peptide is secreted during the Notch signaling pathway. Presenilin (PS)-dependent intramembrane proteolysis cleaves the Notch receptor at multiple sites, resulting in the release of Nβ21 and C-terminally elongated Nβ25, in a process similar to the production of Alzheimer disease-associated β-Amyloid during regulated intramembrane proteolysis (RIP).
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
2694.2 g/mol
Reference/Citations:
  1. Okochi, M. et al. J Biol Chem 281, 7890 (2006).