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N36, HR1, gp41 HIV Fragment

N36, HR1, gp41 HIV Fragment
Sequence (1LC):
SGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL
Sequence (3LC):
H - Ser - Gly - Ile - Val - Gln - Gln - Gln - Asn - Asn - Leu - Leu - Arg - Ala - Ile - Glu - Ala - Gln - Gln - His - Leu - Leu - Gln - Leu - Thr - Val - Trp - Gly - Ile - Lys - Gln - Leu - Gln - Ala - Arg - Ile - Leu - OH
Catalog :
12146-01
Unit:
1 mg
Price/Unit:
$1,436  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Lyophilized solid, trifluoroacetate (TFA) salt format
Description:

This peptide belongs to the helical region of gp41 of HIV which contains  two heptad repeat regions, N heptad and C heptad, which are highly conserved. It is believed that the heptad repeat regions in gp41 self assemble into a six-helix bundle structure (or trimer of hairpins) that likely represents a fusion-active conformation of gp41 that forms after receptor binding and is critical for membrane fusion. This structure consists of a triple stranded coiled coil formed by a trimer of N heptads. The C heptads pack in the grooves of the coiled coil in an antiparallel manner

 
Storage:
-20°C
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
4122.8
Reference/Citations:
  1. Chan et al. , 1997, Cell, 89 : 263-273
  2. Tan et al. , 1997, Proc.