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MOG (35 - 55) mouse rat (12668-10)

MOG (35 - 55) mouse rat (12668-10)
Sequence (1LC):
MEVGWYRSPFSRVVHLYRNGK
Sequence (3LC):
H - Met - Glu - Val - Gly - Trp - Tyr - Arg - Ser - Pro - Phe - Ser - Arg - Val - Val - His - Leu - Tyr - Arg - Asn - Gly - Lys - OH
Catalog :
12668-10
Unit:
10 mg
Price/Unit:
$800  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
Myelin oligodendrocyte glycoprotein (MOG) 35-55, a minor component of CNS myelin,  is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. It is believed to be a target autoantigen in multiple sclerosis. MOG 35-55 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. This Cysteine containing MOG (35-55) peptide can be use to induced polyclonal anti-MOG(35-55) antibody production in rabbits with high specificity, high affinity, and high titer indicating its high purity, as well as suitability for peptide-coated ELISA and Western blot assay. Immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
Storage:
-20°C
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
2582
Reference/Citations:
  1. Encinas, J. et al. Nature Genetics 21, 158 (1999)
  2. Hisahara, S. EMBO J. 19, 341 (2000)
  3. Ford, M. and BJ. Evavold, Immunol. 171, 1247 (2003)
  4. Kort, J. et al. J. Neuroimmunol. [Epub ahead of print] Dec 28, (2005).