[Lys(Me1)79] - Histone H3 (58 - 89)
[Lys(Me1)79] - Histone H3 (58 - 89)
Sequence (1LC):
TELLIRKLPFQRLVREIAQDF-K(Me1)-TDLRFQSAAI
Sequence (3LC):
NH2 - Thr - Glu - Leu - Leu - Ile - Arg - Lys - Leu - Pro - Phe - Gln - Arg - Leu - Val - Arg - Glu - Ile - Ala - Gln - Asp - Phe - Lys(Me1) - Thr - Asp - Leu - Arg - Phe - Gln - Ser - Ala - Ala - Ile - COOH
Price/Unit:
$945
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Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This peptide is histone H3 58-89 with monomethylation at Lys79. Lys79 methylation is mediated by DOT1 protein. Hypermethylation at Lys79 is associated with active gene transcription while hypomethylation is associated with transcriptional silencing. Hypomethylation at Lys79 is associated with Sir1 silencing proteins, which further block methylation by DOT1.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Reference/Citations:
Schubeler, D. et al. Gene Dev 18, 1263 (2004); Ng, H. et al. Proc Natl Acad Sci USA 100, 1820 (2003); Feng, Q. et al. Curr Biol 12, 1052 (2002).
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