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GGTase Substrate, Fluorogenic

GGTase Substrate, Fluorogenic
Sequence (1LC):
Dansyl-GCVLL
Sequence (3LC):
Dansyl Gly-Cys-Val-Leu-Leu
Catalog :
13683-01
Unit:
1 mg
Price/Unit:
$963  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:

A highly selective substrate for continuously monitoring GGTase-I activity (Km = 5 µM) in the presence of geranylgeranyl diphosphate.
S-Geranylgeranylation of the cysteine moiety results in a significant enhancement in fluorescence intensity (? = 460 nm)
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Formula:
C34H52N6O8S2
M.W.:
736.94 g/mol
Reference/Citations:

Reference:

  1. ZHANG, F.Ll, and Casey, P.J. 1996. Biochem. J. 320 (925–932)
  2. Laurence Goossens et. al.  Journal of Pharmaceutical and Biomedical Analysis, Volume 37, Issue 3, 9 March 2005, Pages 417-422
  3. Clausen, V.A., et al. 2001. Biochemistry 40, 3920
  4. Pickett, W.C., et al. 1995. Anal. Biochem. 225, 60.