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Caspase 1 Inhibitor VIII

Caspase 1 Inhibitor VIII
Sequence (1LC):
Ac-WEHD-CHO
Sequence (3LC):
Ac - Trp - Glu - His - Asp - CHO
Catalog :
10809-01
Unit:
1 mg
Price/Unit:
$458  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Lyophilized solid, trifluoroacetate (TFA) salt format
Description:
The tetrapeptide sequence WEHD (Trp-Glu-His-Asp) has been found to be the optimal tetrapeptide recognition sequence for one of the caspases, IL1-beta Convertase. Some other caspases (caspase-4, caspase-5) also prefer this tetrapeptide sequence. The synthetic compound N-Acetyl-WEHD-aldehyde (Ac-WEHD-CHO) has been shown to be a potent inhibitor for this enzyme.
Storage:
-20°C
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
611.6
Reference/Citations:
  1. Thornberry NA et al A combinatorial approach defines specificities of members of the caspase family and granzyme B. Journal of Biological Chemistry 272: 17907-17911 (1997)
  2. Garcia-Calvo M et al Inhibition of human caspases by peptide-based and macromolecular inhibitors. Journal of