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[Arg(Me2s)2, Lys(Me3)4] - Histone H3 (1 - 21) - GGK(Biotin)

[Arg(Me2s)2, Lys(Me3)4] - Histone H3 (1 - 21) - GGK(Biotin)
Sequence (1LC):
A-R(Me2s)-T-K(Me3)-QTARKSTGGKAPRKQLAGG-K(Biotin)
Sequence (3LC):
NH2 - Ala - Arg(Me2s) - Thr - Lys(Me3) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - COOH
Catalog :
14162-005
Unit:
0.5 mg
Price/Unit:
$1,013  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This peptide is histone H3 (1-21) with symmetrical dimethylation at Arg2 and trimethylation at Lys4, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Dimethylation of the guanidinium group of Arg2 is associated with transcriptional silencing. Trimethylation of Lys4, which is catalyzed by Set1, is associated exclusively with active euchromatic genes. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
2793.2g/mol
Reference/Citations:
Musselman, CA and TG. Kutateladze Mol Interv 9, 314 (2010); Kirmizis, A. et al. Nat Struct Mol Biol 16, 449 (2009); Tamaru, H. et al. Nat Genet 34, 75 (2003); Santos-Rosa, H. et al. Nature 419, 407 (2002).