[Arg(Me2s)2, Lys(Me2)4] - Histone H3 (1 - 21) - GGK(Biotin)
[Arg(Me2s)2, Lys(Me2)4] - Histone H3 (1 - 21) - GGK(Biotin)
Sequence (1LC):
A-R(Me2s)-T-K(Me2)-QTARKSTGGKAPRKQLAGG-K(Biotin)
Sequence (3LC):
NH2 - Ala - Arg(Me2s) - Thr - Lys(Me2) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - COOH
Price/Unit:
$1,047
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Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This peptide is histone H3 (1-21) with symmetrical dimethylation at Arg2 and dimethylation at Lys4, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Dimethylation of the guanidinium group of Arg2 is associated with transcriptional silencing. Set1 methyltransferase catalyzes dimethylation of Lys4, which has been associated with inactive and active euchromatic genes. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Reference/Citations:
Musselman, CA and TG. Kutateladze Mol Interv 9, 314 (2010); Kirmizis, A. et al. Nat Struct Mol Biol 16, 449 (2009); Bernstein, B. et al. Proc Natl Acad Sci USA 99, 8695 (2002); Santos-Rosa, H. et al. Nature 419, 407 (2002).
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