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Amyloid Toxicity Inhibitor Peptide 110

Amyloid Toxicity Inhibitor Peptide 110
Sequence (1LC):
RGTWEGKW-CONH2
Sequence (3LC):
NH2 - Arg - Gly - Thr - Trp - Glu - Gly - Lys - Trp - CONH2
Catalog :
13911-01
Unit:
1 mg
Price/Unit:
$579  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This peptide is a modification of the amyloid toxicity inhibitor peptide 11 with Trp4 and Trp8 replacing Gly4 and Gly8 of the original peptide. This peptide is highly effective in blocking beta-amyloid 1 to 40 fibrillization. It is the most effective inhibitor among the amyloid toxicity inhibitor peptides group. The observation that the peptide 110 is able to depolymerize mature b-amyloid 1 to 40 supports the view that these are dynamic structures and suggests that targeting beta-sheet packing may be an effective strategy for depolymerizing amyloid plagues.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
1018.2 g/mol
Reference/Citations:
  1. Sato, T. et al. Biochem. 45, 5509 (2006).