Contact Us
800.227.0627

Amyloid Precursor Protein, (APP) (667 - 676), FRET

Amyloid Precursor Protein, (APP) (667 - 676), FRET
Sequence (1LC):
Mca-SEVKMDAEFR-Dap(Dnp)-CONH2
Sequence (3LC):
Mca - Ser - Glu - Val - Lys - Met - Asp - Ala - Glu - Phe - Arg - DAP(DNP) - CONH2
Catalog :
10266-01
Unit:
1 mg
Price/Unit:
$1,553  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This amino acids 667 to 676 fragment of the amyloid precursor protein (APP) is a beta secretase substrate containing an Mca/ Dap(Dnp) FRET pair. Beside being cleaved by beta-site APP cleavage enzyme (BACE) between the Met and Asp residues, it can also be cleaved by the enzyme thimet oligopeptidase (TOP), Ex/Em=330 nm/390 nm.
Storage:
-20°C
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
1678.8
Reference/Citations:
  1. Koike, H. et al. J. Biochem. 126, 235 (1999);
  2. Grüninger-Leitch, F. et al. J. Biol. Chem. 277, 4687 (2002);
  3. Verheijen, J. et al. Clin. Chem. 52, 1168 (2006).