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Amylin(20 - 29), Islet Amyloid Polypeptide, IAPP (20 - 29), rat

Amylin(20 - 29), Islet Amyloid Polypeptide, IAPP (20 - 29), rat
Sequence (1LC):
SNNLGPVLPP
Sequence (3LC):
NH2 - Ser - Asn - Asn - Leu - Gly - Pro - Val - Leu - Pro - Pro - COOH
Catalog :
13726-01
Unit:
1 mg
Price/Unit:
$599  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
This is amino acids 20 to 29 fragment of the rat islet amyloid polypeptide (IAPP) or corresponding amylin fragment. This rat, hamster and degu IAPP sequence does not give rise to fibrils. Only a small number of animal species including human and cat is known to show amyloidogenesis with this sequence. The sequence Ala-Ile-Leu-Ser-Ser, corresponding to positions 25 to 29 of human IAPP, is strongly amyloidogenic. Proline-for-serine substitution in position 28, found in several rodents including rat, almost completely inhibits formation of amyloid fibrils.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
M.W.:
1007.2 g/mol
Reference/Citations:
  1. Zanuy, D. et al. Biophys. J. 84, 1884 (2003);
  2. Westermark, P. et al. PNAS 87, 5036 (1990).