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Alpha Mating Factor α-Mating Factor

Alpha Mating Factor α-Mating Factor
Sequence (1LC):
WHWLQLKPGQPMY
Sequence (3LC):
H - Trp - His - Trp - Leu - Gln - Leu - Lys - Pro - Gly - Gln - Pro - Met - Tyr - OH
Catalog :
13396-01
Unit:
1 mg
Price/Unit:
$828  (For other quantities please Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Purity:
>95%
Format:
Lyophilized
Description:
Alpha mating peptide, WHWLQLKPGQPMY, yeast α-Factor mating pheromone, is a tridecapeptide initiate sexual conjugation in the yeast Saccharomyces cereuisiae. Its congnate GPCR activate a G protein signal pathway that highly conserves with mammalian signaling pathways. This phenomenon is an ideal paradigm for studying the mode of action of mammalian peptide hormones, 1H-nmr spectroscopy was used to examine the conformation of linear and cyclic analogues of the α-factor (WHWLQLKPGQPMY) in aqueous solution. In all cases peptides that exhibit nmr parameters expected for a type II β-turn have higher biological activities than those that do not appear to assume this conformation.
Storage:
Store this peptide in its dry form at 4C. For best
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Formula:
C82H114N20O17S
M.W.:
1684
NCBI Accession Number:
P34165
GI Number:
462595
Reference/Citations:
  1. Brake,A.J., Brenner,C., Najarian,R., Laybourn,P. and Merryweather,J.
    Structure of genes encoding precursors of the yeast peptide mating pheromone a-factor
  2. Michaelis,S. and Herskowitz,I., et al.
    The a-factor pheromone of Saccharomyces cerevisiae is essential for mating
  3. Jacq,C., Alt-Moerbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.G., Bargues,M., Baron,L., Becker,A., Biteau,N.,, et al.
    The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
  4. Marsischky,G., Rolfs,A., Richardson,A., Kane,M., Baqui,M., Taycher,E., Hu,Y., Vannberg,F., Weger,J., Kramer,J., Moreira,D.,, et al.
    Direct Submission
  5. Betz,R., Crabb,J.W., Meyer,H.E., Wittig,R. and Duntze,W., et al.
    Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae
  6. Brake A.J., Brenner C., Najarian R., Laybourn P., Merryweather J.
    Structure of genes encoding precursors of the yeast peptide mating pheromone a-factor.
  7. Michaelis S., Herskowitz I.
    The a-factor pheromone of Saccharomyces cerevisiae is essential for mating.
  8. Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., et al.
    The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
  9. Marsischky G., Rolfs A., Richardson A., Kane M., Baqui M., Taycher E., Hu Y., Vannberg F., Weger J., Kramer J., et al.
    Creation of the YFLEX clone resource: cloning of Saccharomyces cerevisiae ORFs in the Gateway recombinational cloning system.
  10. Betz R., Crabb J.W., Meyer H.E., Wittig R., Duntze W.
    Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae..