Bioconjugation Service by Molecules

Biopolymers can be cross linked to form hybrid conjugates with two complementary functions. These conjugates can be used as either drug toxins for therapeutic delivery or chelating agents for radioimmunoconjugate adjuvants to increase immuno response.

In the table below, the left column describes a conjugate type while the right column described the application in which that conjugate is used.

Type of conjugate

• Oligonucleotide-antibody conjugates
• Conjugation of Fluorophore (fluorescent dye, biotin/avidin)
• Oligonucleotide-carrier protein conjugates
• Peptide-carrier protein conjugates
• Carbohydrate-carrier protein conjugates
• Antibody-beads conjugates
• Antibody-drug conjugates (ADC)
• Polymer-drug-target ligand conjugation (RGD, EPR, DOTA)
• Oligonucleotide-beads conjugates
• siRNA-antibody conjugates with cleavable linker
• siRNA-cationic peptide conjugates
• Phycoerythrin-antibody conjugates
• Carbohydrate-carrier protein conjugates
• Drug-protein conjugates
• Drug-KLH conjugates

Application corresponding to conjugate from the left column

• Immuno PCR
• Molecule biology tools
• Production of anti-oligonucleotide antibodies
• Production of anti-peptide antibodies
• Production of anti-carbohydrate antibodies
• Diagnostic assays
• Targeted drug delivery
• Targeted Imaging
• Diagnostic assays
• siRNA delivery, gene knockdown experiments
• siRNA delivery, gene knockdown experiments
• Immuno detection
• Drug delivery
• Production of anti-drug Antibodies

Oligo, Nucleic Acids Bioconjugation

Oligonucleotides, oligomimetic modification and biomolecule conjugation

Peptide, Amino Acid Bioconjugations

Synthesis, modification, conjugation of peptides or amino acids to biomolecules

Protein Modification and Bioconjugation

Conjugation of albumins, enzyme, natural or expressed protein to biopolymers and polymers

Glycoconjugates

Conjugation and modification of carbohydrates to amino acids, peptides, protein and oligos

Antibodies, AB Fragment Conjugates

Conjugation of albumins, enzyme, natural or expressed protein to biopolymers and polymers

Enzyme Modification and Conjugation

HRP, AP and other enzyme biomolecule conjugations

Liposome Conjugates and Derivatives

Labeling or conjugation of liposomes to antigens, haptens, biotins /avidins, or proteins

Reporter Molecule Labeling

Conjugation of labels, tags or probes with protein, nucleic acids and others molecules.

PEGylation

Polyethylene glycol (PEG) and dextran biomolecule conjugates for drug delivery

Drug Modification and Bioconjugation

Conjugation of anticancer agents, antibiotic drugs, with proteins, and nucleic acids

Macrocyclics Metal Chelators

Metal chelator , DOTA, NOTA, DTPA, conjugates for diagnostics and radiotherapy

Dendritic Bioconjugation

Dendrimers or dentrons such as PAMAM can be conjugated to biopolymers

Luminex Bead

Incorporation of dye latex particles such as Luminex technology for multiplex detection

Gold Nanoparticle Conjugates

Metal chelator , DOTA, NOTA, DTPA, conjugates for diagnostics and radiotherapy

Microparticles and Nanoparticles

Polymeric microsphere and nanosphere biopolymer conjugation for assay and detection system

Small Molecule Bioconjugation

Conjugation or mixture of any bioconjugates with small molecules