Gene
|
Chromosome
|
Precursor
|
Active Peptides
|
Opioid gene family
|
|
|
|
Pro-enkephalin gene (PENK)
|
8q12.1
|
Prepro-enkephalin
|
Leu-enkephalin,
Met-enkephalin,
amidorphin,
adrenorphin,
peptide B,
peptide E,
peptide F,
BAM22P
|
Pro-opiomelanocortin
gene (POMC
|
2q12.2
|
POMC
|
α-Melanocyte-stimulating hormone
(α -MSH), γ-melanocyte-stimulating
hormone (γ -MSH),
β-melanocytestimulating
hormone (β-MSH),
adrenocorticotropic hormone (ACTH),
β-endorphin,
α-endorphin,
γ-endorphin,
β-lipoprotein (β-LPH),
γ-lipoprotein (γ -LPH),
corticotropinlike intermediate peptide (CLIP)
|
Pro-dynorphin gene
(PDYN)
|
20p13
|
Prepro-dynorphin
|
Dynorphin A,
dynorphin B,
α-neoendorphin,
β-neo-endorphin,
dynorphin-32,
leu-morphin
|
Orphanin gene,
prepro-nociceptin
gene (PNOC)
|
8p21.1
|
Prepro-nociceptin,
Prepro-orphanin
|
Nociceptin (orphanin FQ),
neuropeptide 1,
neuropeptide 2
|
Vasopressin/oxytocin gene family
|
|
|
|
Vasopressin gene (AVP)
|
20p13
|
Prepro-vasopressin- neurophysin II
|
Vasopressin (VP),
neurophysin II (NP II),
C-terminal glycopeptide CPP
|
Oxytocin gene (OXT)
|
20p13
|
Prepro-oxytocin-neurophysin I
|
Oxytocin (OT),
neurophysin I (NP 1)
|
CCK/gastrin gene family
|
|
|
|
Gastrin gene (GAST)
|
17q21.2
|
Prepro-gastrin
|
Gastrin-34,
gastrin-17,
gastrin-4
|
Cholecystokinin gene(CCK)
|
3p22.1
|
Prepro-CCK
|
CCK-8,
CCK-33,
CCK-58
|
Somastostatin gene family
|
|
|
|
Somastostatin gene (SST)
|
3q27.3
|
Prepro-somatostatin
|
SS-12,
SS-14,
SS-28,
antrin
|
Cortistatin gene (CST)
|
1p36.22
|
Prepro cortistatin
|
cortistatin 29,
cortistatin 17
|
F- and Y-amide gene family
|
|
|
|
Gonadotropin inhibitory hormone gene, RF-amide related peptide gene(RFRP)
|
7p15.2
|
Prepro-NPRF
|
QRF-amide
neuropeptide RF-amide,
GnIH,
p518,
RF-related peptide-2,
RF-related peptide-1,
RF-related peptide-3,
neuropeptide VF
|
Neuropeptide FF gene (NPFF)
|
12q13.13
|
Prepro-NPFF
|
Neuropeptide FF,
neuropeptide AF,
neuropeptide SF
|
|
|
|
|
Neuropeptide Y gene (NPY)
|
7p15.3
|
Prepro-NPY
|
NPY,
C-flanking peptide CPON
|
Pancreatic polypeptide gene (PPY)
|
17q21.31
|
Prepro-PPY
|
PPY
|
Peptide YY gene (PYY)
|
17q21.31
|
Prepro-PYY
|
PYY, PYY-(3-36)
|
Prolactin-releasing peptide (PRLH)
|
2q37.3
|
Prepro-PrRP
|
PrRP-31, PrRP-20
|
Calcitonin gene family
|
|
|
|
Calcitonin I gene (CALCA)
|
11p15.2
|
Prepro-CALC
|
Calcitonin,
katacalcin
|
Calcitonin II gene (CALCB)
|
11p15.2
|
Prepro-CGRP-alpha
Prepro-CGRP-beta
|
Calcitonin gene related peptide I (-CGRP)
Calcitonin gene related peptide II (-CGRP)
|
Islet amyloid polypeptide gene (IAPP), Amylin gene
|
12p12.1
|
Prepro-IAPP
|
IAPP
amylin,
amyloid polypeptide
|
Adrenomedullin gene (ADM)
|
11p15.4
|
Prepro-adrenomedullin
|
Adrenomedullin,
AM,
PAMP
|
Adrenomedullin-2 gene (ADM2)
|
22q13.33
|
Prepro-adrenomedullin-2
|
Adrenomedullin-2,
intermedin-long (IMDL),
intermedin-short (IMDS)
|
Natriuretic factor gene family
|
|
|
|
Atrial natriuretic factor gene (NPPA)
|
1p36.22
|
Prepro-ANP
|
Atrial natriuretic factor
natriuretic peptide A,
ANF,
ANP,
natriodilatine,
cardiodilatine-related peptide
|
Brain natriuretic factor gene (NPPB)
|
1p36.22
|
Prepro-BNP
|
Brain natriuretic factor
natriuretic peptide B,
BNF,
BNP
|
Natriuretic peptide precursor C gene (NPPC)
|
2q37.1
|
Prepro-CNP
|
C-type natriuretic peptide (CNP-23),
CNP-29,
CNP-53
|
Bombesin-like peptide gene family
|
|
|
|
Gastrin-releasing peptide gene (GRP)
|
18q21.32
|
Prero-GRP-1
Prepro-GRP-2
Prepro-GRP-3
|
GRP-27, GRP-14, GRP-10 (neuromedin C)
GRP-27, GRP-14, GRP-10 (neuromedin C)
GRP-27, GRP-14, GRP-10 (neuromedin C)
|
Neuromedin B gene (NMB)
|
15q25.2-q25.3
|
Prepro-neuromedin B1
Prepro-neuromedin B2
|
Neuromedin B (Ranatensin-like peptide, RLP)
Neuromedin B (Ranatensin-like peptide, RLP)
|
Endothelin gene family
|
|
|
|
Endothelin 1 gene (EDN1)
|
6p24.1
|
Prepro-endothelin 1 (PPET1)
|
Endothelin 1 (ET-1)
|
Endothelin 2 gene (EDN2)
|
1p34.2
|
Prepro-endothelin 2 (PPET2)2
|
Endothelin 2 (ET-2)
|
Endothelin 3 gene (EDN3)
|
20q13.32
|
Prepro-endothelin 3 (PPET3)
|
Endothelin 3 (ET-3)
|
Glucagon/secretin gene family
|
|
|
|
Glucagon gene (CGC)
|
2q24.2
|
Prepro-glucagon
|
Glicentin;
Glicentin-related polypeptide (GRPP);
Oxyntomodulin (OXY) (OXM);
Glucagon;
Glucagon-like peptide 1 (GLP-1);
Glucagon-like
peptide 1 (7-37) (GLP-1 (7-37)); Glucagon-like peptide 1 (7-36) (GLP-1 (7-36)); Glucagon-like peptide 2 (GLP-2)
|
Secretin gene (SCT)
|
11p15.5
|
Prepro-secretin
|
Secretin
|
Vasoactive intestinal peptide gene (VIP)
|
6q25.2
|
Prepro-VIP-1
Prepro-VIP-2
|
VIP, PHM-27/PHI-27, PHV-42,
VIP, PHM-27/PHI-27, PHV-42
|
Pituitary adenyl cyclaseactivated
peptide gene (ADCYAP1)
|
20q11.23
|
Prepro-GHRH
|
GHRH
somatoliberin,
GRF,
somatocrinin,
somatorelin,
sermorelin
|
Gastric inhibitory peptide gene (GIP)
|
17q21.32
|
Prepro-GIP
|
gastric inhibitory peptide (GIP)
glucosedependent insulinotropic polypeptide
|
Corticotropin-releasing hormone gene (CRH)-related gene family
|
|
|
|
Corticotropin-releasing hormone gene (CRH)
|
8q13.1
|
Prepro-CRH
|
CRH
|
Urocortin gene (UCN)
|
2p23.3
|
Prepro-UNC I
|
UNC I
|
Urocortin II gene (UCN2)
|
3p21.31
|
Prepro-UNC II
|
UNC II,
stresscopin-related peptide
|
Urocortin III gene (UCN3)
|
10p15.1
|
Prepro-UNC III
|
UNC III,
stresscopin
|
Urotensin-II (UTS2)
|
1p36.23
|
Prepro-urotensin-2,isoform a
Prepro-urotensin-2, isoform b
|
Urotensin-2
Urotensin-2
|
Urotensin-II domain containing (UTS2D)
|
3q28
|
Prepro-urotensin-2B
|
Urotensin-2-related peptide,urotensin-2B
|
Kinin and tensin gene family
|
|
|
|
Preprotachykinin A gene (TAC1)
|
7q21.3
|
α-PPTA
β-PPTA
γ-PPTA
d-PPTA
|
Substance P,
neurokinin A (NKA),
substance K,
neuromedin L,
neuropeptide K,
neuropeptide gamma
Substance P,
neuropeptide K,
neurokinin A
Substance P,
neurokinin A,
neuropeptide γ
Substance P,
neuropeptide K,
neurokinin A
|
Preprotachykinin B gene (TAC3)
|
12q13.3
|
PPTB, isoform 1
PPTB, isoform 2
|
Neuromedin K,
neurokinin B
Neuromedin K,
neurokinin B
|
Neuromedins
|
|
|
|
Neuromedin S gene (NMS)
|
2q11.2
|
Prepro-neuromedin S
|
Neuromedin S
|
Neuromedin U gene (NMU)
|
4q12
|
Prepro-neuromedin U, multiple isoforms
|
Neuromedin U
|
Tensins and Kinins
|
|
|
|
Kininogen-1 gene (KNG1)
|
3q27.3
|
Kininogen-1 precursor, isoform 1
Kininogen-1 precursor, isoform 2
|
Bradykinin,
kallidin,
LMW-K-kinin,
HMW-K-kinin
Bradykinin,
kallidin,
LMW-K-kinin,
HMW-K-kinin
|
|
|
|
|
Angiotensin gene (AGT)
|
1q42.2
|
Angiotensinogen preprotein
|
Angiotensin I,
angiotensin II,
angiotensin-(1–7)
|
Neurotensin gene (NTS)
|
12q21.31
|
Prepro-neurotensin
|
Neurotensin (NT),
neuromedin N
|
Motilin family
|
|
|
|
Motilin gene (MLN)
|
6p21.31
|
Prepro-motilin isoform 1
Prepro-motilin isofrom 2
|
Motilin,
motilin-associated peptide
Motilin,
motillin-associated peptide
|
Ghrelin gene (GHRL)
|
3p25.3
|
Prepro-ghrelin isoform 1
Prepro-ghrelin isoform 2
Prepro-ghrelin isoform 3
Pro-obestatin
Prepro-ghrelin isoform 4,
Pro-obestatin
Prepro-ghrelin isoform 5
|
Ghrelin, obestatin
Ghrelin, obestatin
Obestatin
Obestatin
Obestatin
|
Galanin family
|
|
|
|
Galanin gene (GAL)
|
11q13.2
|
Prepro-galanin
|
Galanin,
galanin message associated peptide (GMAP)
|
Galanin-like peptide precursor gene (GALP)
|
19q13.42
|
Galanin-like peptide precursor
|
Galanin-like peptide (GALP)
|
GnRH family
|
|
|
|
Gonadotropin-releasing hormone gene (GnRH1)
|
8p21.2
|
Prepro-GnRH1
|
GnRH
LHRH,
gonadoliberin
|
Gonadotropin-releasing hormone gene (GnRH2)
|
20p13
|
Prepro-GNRH2, Isoform-a
Prepro-GNRH2, Isoform-b
Prepro-GNRH2, Isoform-c
|
GnRH2
LHRH II,
gonadoliberin II
GnRH2
LHRH II,
gonadoliberin II
GnRH2
(LHRH II,
gonadoliberin II)
|
Neuropeptide B/W family
|
|
|
|
Neuropeptide B gene (NPB)
|
17q25.3
|
Prepro-neuropeptide B, PPL7
|
Neuropeptide B-23
(peptide L7),
neuropeptide B-29
|
Neuropeptide W gene (NPW)
|
16p13.3
|
Prepro-neuropeptide W, PPL8
|
Neuropeptide W-23 (peptide L8),
neuropeptide W-30
|
Neuropeptides S gene (NPS)
|
10q26.2
|
Prepro-neuropeptide S
|
Neuropeptide S
|
Insulin/relaxins
|
|
|
|
Relaxin-1 gene (RLN1)
|
9p24.1
|
Prepro-relaxin-1
|
Relaxin-1
|
|
|
|
|
Relaxin-2 gene (RLN2)
|
9p24.1
|
Prepro-relaxin-2,isoform 1
Prepro-relaxin-2, Isoform 2
|
Relaxin-2
Relaxin-2
|
Relaxin-3 gene (RLN3)
|
19p13.12
|
Prepro-relaxin-3
|
Relaxin-3
|
No-family neuropeptides
|
|
|
|
Thyrotropin-releasing hormone gene (TRH)
|
3q21.3
|
Prepro-TRH
|
TRH (thyroliberin)
|
Parathyroid hormone-like hormone gene (PTHLH)
|
12p11.22
|
Prepro-PTH-like hormone, isoform CRA_α
Prepro-PTH-like hormone, isoform CRA_β
|
PTHrP-(1-36),
PTHrP-(38-94),
PTHrP-(107-139)
(osteostatin)
|
Melanin-concentrating hormone gene (PMCH)
|
12q23.2
|
Prepro-MCH
|
MCH,
neuropeptide Glu-Ile (NEI),
neuropeptide Gly-Glu (NGE)
|
Hypocretin gene (HCRT)
|
17q21.2
|
Prepro-hypocretin
|
Hypocretin-1 (orexin A),
hypocretin-2 (orexin B)
|
Cocaine- and amphetamine-regulated transcript gene (CART)
|
5q13.2
|
Prepro-CART
|
CART-(1-39), CART-(42-89)
|
Agouti-related protein homolog gene (AGRP)
|
16q22.1
|
AGRP precursor isoform 1
Prepro-AGRP isoform 2
|
AGRP
AGRP
|
Prolactin (PRL)
|
6p22.3
|
Prolactin precursor
|
Prolactin
|
Apelin gene (APLN)
|
Xq25
|
Prepro-apelin
|
Apelin-13,
apelin-17,
apelin-36 (APJ ligand,
AGTRL1 ligand)
|
Metastasis-suppressor KiSS (KISS1)
|
1q32.1
|
Kiss-1
|
Metastin (kisspeptin-54),
(golgi transport 1 homolog A,golt1a), kisspeptin-14,
kisspeptin-13,
kisspeptin-10
|
Diazepam-binding inhibitor (DBI)
|
2q14.2
|
DBI isoform 1
DBI isoform 2
DBI isoform 3
|
Diazepam-binding inhibitory peptide
Diazepam-binding inhibitory peptide
Diazepam-binding inhibitory peptide
|
Prokineticin-1 (PROK1)
|
1p13.3
|
Prokineticin-1 precursor
|
Prokineticin-1,
(PK1) endocrine gland derived VEGF (EGVEGF)
|
Prokineticin-2 (PROK2)
|
3p13
|
Prokineticin-2 precursor isoform 1
Prokineticin-2 precursor isoform
|
Prokineticin-2 (PK2)
Prokineticin-2 (PK2)
|
|
|
|
2
|
Augurin (C2orf40)
|
2q12.2
|
Augurin precursor
|
Augurin
(esophageal cancer related gene 4, ECRG-4)
|
Spexin (C12orf39)
|
12p12.1
|
Spexin precursor
|
Spexin
|
Periostin (POSTN)
|
13q13.3
|
Periostin precursor, isoform 1
Periostin precursor isoform 2
Periostin precursor isoform 3
Periostin precursor isoform 4
|
Periostin
(Osteoblast-specific factor 2 (OSF-2),
fasciclin I-like)
Periostin
(Osteoblast-specific factor 2 (OSF-2), fasciclin I-like)
Periostin
(Osteoblast-specific factor 2 (OSF-2), fasciclin I-like)
Periostin (Osteoblast-specific factor 2 (OSF-2), fasciclin I-like)
|
Osteocrin (OSTN)
|
3q28
|
Osteocrin precursor
|
Osteocrin (musclin)
|