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Citrullinated Peptide

Citrullinated Peptide

Bio-Synthesis provides citrullinated peptide synthesis and antibodies.  Citrullination plays an important role in controlling gene expression, particularly in the developing embryo, and because the immune system often attacks citrullinated proteins, leading to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. This post-translation modification of amino acid in which citrullination is distinct from the formation of the free amino acid citrulline as part of the metabolism pathway found in many terrestric vertebrates. In this pathway, unwanted ammonia is being deoxtified and eliminated. It is also produced from arginine as a byproduct of the reaction cataloyzed by the nitric oxide synthease (NOS) family. Citrullinated peptides are often used as tools for diagnosis and treatment. In 2006, Holm, et. al1, have shown Immune reactions to citrulline-containing proteins appear to be central in the immunopathogenesis of rheumatoid arthritis. Anti-citrullinated peptide antibody( CCP) are been used specific to test for Rheumatoid Arthritis (RA) and can be detected very early in the course of the disease. 
citrulline peptides


References:
  1. A. Holm et. al. "Specific modification of peptide-bound citrulline residues", May 2006, Vol. 352, Issue 1, pp 68-76

    2. 09/13