Bio-Synthesis - the world leader in custom services since 1984.
With the industry growing so rapidly, there are “young” companies sprouting all over the place. Many of these same companies are not successful and do not last very long. Bio-Synthesis has been the world leader in custom services since our inception in 1984. Over two decades of the highest quality of products, coupled with fast turnaround time and affordability has enabled BSI to stand in no one else’s shadow. Go with a company you know you can trust. Go with a company who cares about your research needs as much as you do. Whether its peptides, antibodies, DNA, RNA, or PNA, BSI will treat your needs like our own. Contact us now for your next quote, and see the difference a well-established company can make.
Synthesis of Novel Backbone Modified DNA
Bio-Synthesis inc., senior scientists Drs Jianhua Ye and Miguel Castro completed the synthesis of a new kind of modified DNA. Normally there is a phosphodiester backbone linking the nuecleotides in a DNA strand, however hese diester bonds are susceptible to degradation by DNA'ses, present in living cells. One way to extend the half life of DNA is by modifying the phosphodiester backbone. In this work four monomers were constructed, which upon chemical coupling produce a peptide like backbone which is unaffected by nucleases, thereby increasing the half life of these molecules and consequently extending its intended activity.
Bio-Synthesis announces Mini Gene synthesis services
The DNA Synthesis Division of Bio-Synthesis Inc is happy to announce another custom service: Mini Gene synthesis; with the capability to synthesize 100-200 bases long oligonucleotides we can put together small genes together; a small gene can be defined as one that encodes for 30-60 residuesin length. The ability to chemically synthesize proves very useful to the biomedical researcher that studies control of gene expression; a minigene can code for a peptide that can be an antagonist to a regulatory protein. We can deliver minigenes in about 5-7 days. For more information please call the DNA Synthesis Division.
Bio-Synthesis acquires sophisticated Multiple Peptide Synthesizer
Bio-Synthesis Inc is proud to announce the recent acquisition of a sophisticated Multiple Peptide Synthesizer, the Vantage from ACT, Louiville, Kentucky. This instrument has four dispensor tips, which allows for parallel washings, decreasing cycling times for peptide assembly. The Vantage is also equipped with a heating device which allows use to conduct reactions at 80 degrees Celsius, which expedites coupling times. This unit will help us to prepare a large number of peptides( 96 at a time) for applications such us peptide microarrays and discovery scale peptides; where researcher needs small quantities(imilligram or less) but in large numbers.
Bio-Synthesis releases updated peptide synthesis description
Bio-Synthesis has released an updated description for peptide synthesis; this allows peptide researchers to get a view of the broad spectrum of our capabilities.
Peptides are complex molecules and each peptide sequence is unique with regard to its chemical and physical properties. Peptides are synthesized by the solid-phase method using Fmoc chemistry on an Omega 396 multiple peptide synthesizer from Advanced ChemTech. The Core also uses an Applied Biosystems Model 431A Synthesizer for longer peptides. Synthesis is carried out at 50 µmole, 100 µmole or 250 µmole scales. On an average, a synthesis scale of 100 µmoles will yield about 50-70 mg of a 10-residue peptide and 100-150 mg of a 20-residue peptide depending on the substitution rating of the resin. The peptide synthesis service provides a complete spectrum of services that include, synthesis, cleavage, HPLC purification, peptide modifications, cyclization and mass analysis for quality assurance. Before submitting your peptide sequences to the Core, it is advisable to consider the following:
* Every peptide sequence synthesized is a unique one. Some peptides sequences are difficult to synthesize although, we attempt to synthesize every peptide sequence.
* Peptides with multiple cysteines, methionine, arginine and tryptophan residues can often be difficult to synthesize.
* Avoid a proline residue at the C-terminal of the peptide.
* The peptide will be de-protected and cleaved from the resin with 82.5-90% trifluoroacetic acid, partially purified, and lyophilized. The lyophilized material will be provided as a "crude" preparation. Turnaround time is about ten days to three weeks depending on the length of the peptide and purity level. When requested, the peptide will be purified further (see below).
For further questions please feel free to contact our Peptide Synthesis Division at 1800-227-0627
Peptide-PNA bioconjugates
Our peptide Synthesis Division has successfully developed methods to synthesize bioconjugates such us PNA’s linked to peptides; the hybrid molecule can be up to 60 residues in length and can be half PNA and half peptide linked together or they can be alternating PNA residues with peptide residues. This type of bioconjugates can be used to deliver peptide sequences inside a living cell, by using peptide sequences at one end that have the ability to penetrate the cell membrane and carry along a PNA, that can be targeted to a regulatory DNA sequence, then upon binding to it, it can interfere with its expression( production of a protein).
We are happy to announce that Biosearch Technologies of Novato, California, have extended Bio-Synthesis Inc, of Lewisville, Texas their line of Fluorescent dyes and quenchers for use in biomedical research applications. End users who source Biosearch dyes for any purpose other than non-commercial R&D applications will still be required to contact the Biosearch Technologies Licensing Department to obtain a Commercial Use License. These dyes are chemically couple to synthetic oligonucleotides and provide an excellent means for non-radioactive detection of DNA targets. Bio-Synthesis Inc have been providing custom synthetic oligonucleotides to the biomedical research community worldwide since 1984.
Bio-Synthesis Inc. was contracted by Georgia Cosmetics, Houston ,Texas to produce a series of peptides derived from colostrum. Georgia Cosmetics have filed for patents encompassing said peptides. Colostrum is the early mother’s milk thought to be important in providing the newborn with the elements necessary to establish the immune system of the child. Dr Jersey Georgiadis a world renowned protein expert is the CEO of Georgia Cosmetics, is also marketing tablets containing related peptides and other proprietary formulation that also stimulates an adult’s immune system.
Bio-Synthesis Inc was glad to sponsor the 19th Federation of North Texas Area Scientific Conference; the main speaker Dr. MacDonald from the Biochemistry Department at UT Austin spoke on Regulation of Gene Expression at the Translational Level, this subject is novel and appealing as most gene expression control was thought to be at the transcriptional level. A Texas style BBQ followed the conference where faculty and students of both Texas Woman University and the U. of North Texas had the chance to mingle and exchange with the invited speakers. Bio-Synthesis Inc. has sponsored the Federation meetings since 1,994 and hopes to continue doing so for many years to come.
Bio-Synthesis participates in CCCB Biotechnology Board
Bio-Synthesis Inc CEO Miguel Castro attended and formed part of the Collin County College Biotechnology(CCCB) Advisory Board; the mission of the Board is to advise the College in ways to improve the curriculum and to establish cooperative programs where the CCCB students /graduates perform internships with local biotech companies, where they can learn valuable hands on experience and give the local companies a chance to observe the performance of the students for possible permanent hiring. A number of local universities faculty form part of the board; these universities include: Texas A&M UT Southwestern,UT Dallas, U. of North Texas Health Science Center and other members are senior officers of local biotech companies. The CCCB campus is located in Collin County; Bio-Synthesis Inc is located in the adjacent county of Denton.
